The antagonistic effect of carnitine in hyperthyroidism. L-carnitine, ginseng, guarana, glucose, taurine, and more. View abstract. View abstract. Although not all of these side effects may occur, if they do occur they may need medical attention. Wu X, Huang W, Prasad PD, et al. Plasma carnitine deficiency: Clinical observations in 51 pediatric patients. View abstract. J Nutr.Biochem. Side effects may include nausea, gastrointestinal discomfort, bloating, diarrhea, hives, lower back pain, leg restlessness, numbness, rash, endocrine changes, increased inflammatory response, increased blood urea nitrogen, severe tissue necrosis and venous irritation. 2007;135(11):1446-1449. Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes. 1996;18(1):91-96. Dal Negro R, Pomari G, Zoccatelli O, and et al. Rebouche CJ. 2013 Apr;121(4):234-8. Reported side effects are unusual, but include insomnia, headache, diarrhea, low or high blood pressure, nausea, blurred vision, and chest pains. Gramignano, G., Lusso, M. R., Madeddu, C., Massa, E., Serpe, R., Deiana, L., Lamonica, G., Dessi, M., Spiga, C., Astara, G., Maccio, A., and Mantovani, G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. View abstract. View abstract. Nephrol Dial Transplant 1996;11:A262. Galvano, F., Li, Volti G., Malaguarnera, M., Avitabile, T., Antic, T., Vacante, M., and Malaguarnera, M. Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus. Long-term l-carnitine treatment of chronic anaemia of patients with end-stage renal failure. European multicenter study on propionyl-L-carnitine in intermittent claudication. Medicine (Baltimore). J Eur Acad Dermatol Venereol 1999;13:205-9. Schlenzig JS, Charpentier C, Rabier D, et al. J Diabetes Complications 1999;13:251-3. 2012;13(2):285-293. Tabibi, H., Hakeshzadeh, F., Hedayati, M., and Malakoutian, T. Effects of l-carnitine supplement on serum amyloid A and vascular inflammation markers in hemodialysis patients: a randomized controlled trial. Do not take this medicine in larger or smaller amounts or for longer than recommended. View abstract. Malaguarnera, M., Pistone, G., Astuto, M., Vecchio, I., Raffaele, R., Lo, Giudice E., and Rampello, L. Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial. View abstract. Jpn Circ.J 1992;56(1):86-94. 2000;22(1):73-80. Spiekerkoetter, U., Lindner, M., Santer, R., Grotzke, M., Baumgartner, M. R., Boehles, H., Das, A., Haase, C., Hennermann, J. View abstract. Examples: atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal), sotalol (Betapace), timolol (Timoptic) and some other drugs whose chemical names end with "-olol." How they can cause insomnia: Beta-blockers have long been associated with sleep disturbances, including awakenings at night and nightmares. Casciani, C. U., Caruso, U., Cravotto, E., Corsi, M., Pola, P., Savi, L., and Grilli, M. Effect of L-carnitine on lipid pattern in haemodialysis. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. Horvath, G. A., Davidson, A. G., Stockler-Ipsiroglu, S. G., Lillquist, Y. P., Waters, P. J., Olpin, S., Andresen, B. S., Palaty, J., Nelson, J., and Vallance, H. Newborn screening for MCAD deficiency: experience of the first three years in British Columbia, Canada. 2005;45(6):343-351. Insomnia, headaches and vertigo are common side effects. Calandrella, N., De, Seta C., Scarsella, G., and Risuleo, G. Carnitine reduces the lipoperoxidative damage of the membrane and apoptosis after induction of cell stress in experimental glaucoma. Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. Swiss Med Wkly 2004;134:385. View abstract. Side Effects. View abstract. . J Urol. 2011;46(6):750-759. Kimmoun, A., Munagamage, G., Dessalles, N., Gerard, A., Feillet, F., and Levy, B. View abstract. Eur.J Gastroenterol.Hepatol. Avoid taking ALCAR too late in the day, as it can cause insomnia in some people. J Gerontol.A Biol.Sci Med.Sci 2008;63(10):1027-1033. J Inherit.Metab Dis 2007;30(5):811. 2018 Oct;59(10):2360-2368. Inflammation contributes to many medical conditions, including . Ren Fail. View abstract. Clin Trials J 1988;25:227-237. Does L-carnitine reduce belly fat? Semeniuk, J., Shalansky, K. F., Taylor, N., Jastrzebski, J., and Cameron, E. C. Evaluation of the effect of intravenous l-carnitine on quality of life in chronic hemodialysis patients. However, some individuals may experience digestive side effects when taking L-carnitine. El Sharkwy I, Sharaf El-Din M. l-Carnitine plus metformin in clomiphene-resistant obese PCOS women, reproductive and metabolic effects: a randomized clinical trial. 7-14-2009;89(26):1858-1861. Tsoko M, Beauseigneur F, Gresti J, et al. Jones, S., Reed, C. A., Vijay, S., Walter, J. H., and Morris, A. Sloan, R. S., Kastan, B., Rice, S. I., Sallee, C. W., Yuenger, N. J., Smith, B., Ward, R. A., Brier, M. E., and Golper, T. A. About 98% of your L-carnitine stores are contained in your muscles, along with trace amounts in your liver and blood (17, 18). Cifone MG, Alesse E, Di Marzio L, et al. Pediatr.Nephrol. L-carnitine supplementation has been associated with a significant reduction in all-cause mortality, ventricular arrhythmia, and angina in the setting of acute myocardial infarction (MI). Can carnitine cause insomnia? View abstract. Of the different forms, acetyl-L-carnitine and L-carnitine are the most popular and seem to be most effective. 2007;20(5):499-502. Jing, L., Zhou, L. J., Li, W. M., Zhang, F. M., Yuan, L., Li, S., Song, J., and Sang, Y. Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy. View abstract. Prev Nutr Food Sci 2020;25(2):124-32. Sulkers, E. J., Lafeber, H. N., Degenhart, H. J., Przyrembel, H., Schlotzer, E., and Sauer, P. J. 2007;52(6):1775-1776. Eur Heart J 1996;17:414-20. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. Complement Ther Med 2011;19(4):216-227. A., Kraemer, W. J., Vingren, J. L., Hatfield, D. L., Fragala, M. S., Ho, J. Y., Maresh, C. M., Anderson, J. M., and Volek, J. S. Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. Pucciarelli, G., Mastursi, M., Latte, S., Sacra, C., Setaro, A., Lizzadro, A., and Nolfe, G. [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. View abstract. Wolfe, L. A., He, M., Vockley, J., Payne, N., Rhead, W., Hoppel, C., Spector, E., Gernert, K., and Gibson, K. M. Novel ETF dehydrogenase mutations in a patient with mild glutaric aciduria type II and complex II-III deficiency in liver and muscle. Am J Clin.Nutr 2009;89(1):71-76. Eur Heart J 1994;15:1267-73. Mingrone G. Carnitine in type 2 diabetes. Nootropics are drugs or supplements that can boost brain function. (Paris) 2010;166(3):289-294. Fertil.Steril 2003;80(Suppl 3):48. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. 2014 May;29(5):997-1004. Acta Paediatr Hung 1986;27:253-8. L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial. Prevention of hepatotoxicity recurrence with valproate monotherapy and carnitine. Low levels of L-carnitine have been found to be associated with diabetic complications. Int.J Cancer 9-15-2008;123(6):1227-1239. 2002;2(3):240-243. Brass E. Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients. 2020;9(1):45-54. Levocarnitine-induced hypophosphatemia in a hemodialysis patient with acute valproic acid toxicity. Reprod Biol Endocrinol. View abstract. Muscle carnitine deficiency associated with zidovudine-induced mitochondrial myopathy. Ann.Nutr.Metab 2008;53(2):91-95. Clin Ter 3-31-1990;132(6 Suppl):479-510. Passeri, M., Iannuccelli, M., Ciotti, G., Bonati, P. A., Nolfe, G., and Cucinotta, D. Mental impairment in aging: selection of patients, methods of evaluation and therapeutic possibilities of acetyl-L-carnitine. 2018 May;18(5):e191-e195. Mar.Drugs 2009;7(1):57-70. 1992;140(4):353-377. 2006;35(2):158-161. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. A., and Farok, M. Assessment of puberty in relation to L-carnitine and hormonal replacement therapy in beta-thalassemic patients. Scand.J Clin Lab Invest 1985;45(3):193-198. Curr Med Res Opin 2004;20:1377-84. Brunel-Guitton, C., Costa, T., Mitchell, G. A., and Lambert, M. Treatment of cobalamin C (cblC) deficiency during pregnancy. Tanphaichitr N. In vitro stimulation of human sperm motility by acetylcarnitine. Schmidt-Sommerfeld E, Penn D, Wolf H. Carnitine deficiency in premature infants receiving total parenteral nutrition: effect of L-carnitine supplementation. Rejuvenation.Res. View abstract. Ann N Y Acad Sci 2004;1033:42-51. Zhonghua Er.Ke.Za Zhi. Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage. 1992;141(11):379-384. Kidney Blood Press Res. View abstract. Sood, A., Barton, D. L., Bauer, B. View abstract. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. View abstract. View abstract. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. Pehlivanoglu S, Enar R Mutlu H Sert A Ersalni M Yazicioglu N. The effect of L-carnitine on left ventricular function in patients with acute myocardial infarction treated with streptokinase. Clin Chim Acta 1982;122:369-75. Medically reviewed by Drugs.com on Jun 6, 2022. View abstract. View abstract. Int J Cardiol 1992;34(2):167-172. Antioxidants may fight both inflammation and oxidation in the body. HIV.Med. Eur J Nutr 2022;61(3):1199-1207. Cardiovasc.Drugs Ther 2009;23(4):301-306. L carnitine side effects, safety, danger, caution, risks. 2011;(6):CD003917. Curr Med Res Opin 1990;11:638-47. Am.J Med.Genet.A 4-1-2008;146(7):803-812. BJU.Int. Nutr Metab Cardiovasc Dis 2019;29(11):1151-67. doi: 10.1016/j.numecd.2019.07.012. Diabetes Care 2005;28:89-94. Curr Ther res, Clin exp 1982;32(11):116-127. Cochrane.Database.Syst.Rev. It can also cause the urine, breath, and sweat to have a "fishy" odor. Research suggests that L-carnitine may aid exercise performance and treat health conditions like heart disease and type 2 diabetes. Medical treatment to improve sperm quality. Drugs Exp Clin Res 1999;25:29-36. View abstract. 2012;7(11):1836-1842. View abstract. We comply with the HONcode standard for trustworthy health information. View abstract. View abstract. View abstract. U.S. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Sproule, D. M., Dyme, J., Coku, J., de, Vinck D., Rosenzweig, E., Chung, W. K., and De Vivo, D. C. Pulmonary artery hypertension in a child with MELAS due to a point mutation of the mitochondrial tRNA((Leu)) gene (m.3243A > G). Efficacy of l-carnitine supplementation for management of blood lipids: A systematic review and dose-response meta-analysis of randomized controlled trials. Am J Cardiol. View abstract. Postgrad Med J 1996;72:45-50. Kamikawa, T., Suzuki, Y., Kobayashi, A., Hayashi, H., Masumura, Y., Nishihara, K., Abe, M., and Yamazaki, N. Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris. J Cancer Res.Clin Oncol. 2000;2(2):189-193. Sethumadhavan, S. and Chinnakannu, P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. L-carnitine may increase the risk of seizures in those with epilepsy. Novak M. Carnitine supplementation in soy-based formula-fed infants. Drugs Exp Clin Res 1992;18(4):147-153. Check with your doctor as soon as possible if any of the following side effects occur while taking levocarnitine: Some side effects of levocarnitine may occur that usually do not need medical attention. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. View abstract. View abstract. Borghi-Silva, A., Baldissera, V., Sampaio, L. M., Pires-DiLorenzo, V. A., Jamami, M., Demonte, A., Marchini, J. S., and Costa, D. L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs. View abstract. Liu, S., Wu, H. J., Zhang, Z. Q., Chen, Q., Liu, B., Wu, J. P., and Zhu, L. L-carnitine ameliorates cancer cachexia in mice by regulating the expression and activity of carnitine palmityl transferase. Malaguarnera, M., Vacante, M., Avitabile, T., Malaguarnera, M., Cammalleri, L., and Motta, M. L-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. View abstract. 2010;16(6):504-509. Mantovani, G. Randomised phase III clinical trial of 5 different arms of treatment on 332 patients with cancer cachexia. J Nephrol. Thal LJ, Calvani M, Amato A, et al. Giamberardino, M. A., Dragani, L., Valente, R., di Lisa, F., Saggini, R., and Vecchiet, L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Editorial comment on: Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia. View abstract. View abstract. Lynch, K. E., Feldman, H. I., Berlin, J. Ann.Pharmacother. Pastoris, O., Dossena, M., Foppa, P., Catapano, M., Arbustini, E., Bellini, O., Dal Bello, B., Minzioni, G., Ceriana, P., and Barzaghi, N. Effect of L-carnitine on myocardial metabolism: results of a balanced, placebo-controlled, double-blind study in patients undergoing open heart surgery. Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials. Exp.Physiol 2008;93(10):1139-1146. 1999; Mitwalli, A. H., Al-Wakeel, J. S., Alam, A., Tarif, N., Abu-Aisha, H., Rashed, M., and Al, Nahed N. L-carnitine supplementation in hemodialysis patients. Clin Trial J 1984;21:40-58. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. Martinotti, G., Reina, D., Di, Nicola M., Andreoli, S., Tedeschi, D., Ortolani, I., Pozzi, G., Iannoni, E., D'Iddio, S., and Janiri, L. Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trial. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Dig Dis 2021. View abstract. View abstract. View abstract. Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. View abstract. Int J Sport Nutr Exerc.Metab 2010;20(2):104-114. Huidekoper, H. H., Schneider, J., Westphal, T., Vaz, F. M., Duran, M., and Wijburg, F. A. View abstract. J Autism Dev.Disord. J Strength.Cond.Res. In some people, carnitine can cause fishy body odor, abdominal cramps, nausea, vomiting, muscle weakness, rash, increases in appetite, diarrhea or body odor, especially with the high doses found in supplements. A., Ebenezer, G. J., Hauer, P., Millar, L., Gould, M., Tran, P., Shikuma, C., Souza, S., and McArthur, J. C. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. Drugs Exp Clin Res 1987;13:417-23. Am J Nephrol 1990;10(2):109-114. View abstract. The dose of your warfarin might need to be changed. Kubota K, Uojima H, Shao X, et al. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. Brain Dev. View abstract. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. Bipolar.Disord. 1993;25(6):733-740. Asia Pac.J Clin Nutr. A., Iezhitsa, I. N., Kravchenko, M. S., Pisarev, V. B., and Snigur, G. L. Effects of L-, D-, and DL-carnitine on morphometric parameters of skeletal muscle and exercise performance of laboratory animals receiving carnitine-deficient diet. The word, "carnitine" comes from the Latin word "carnus," meaning meat, because it was first isolated from meat in 1905. Res Pharm Sci. Endocr.J 2010;57(9):777-786. Wyss, V., Ganzit, G. P., and Rienzi, A. Gut. 2007;16(3):168-172. Sarafoglou, K., Tridgell, A. H., Bentler, K., Redlinger-Grosse, K., Berry, S. A., and Schimmenti, L. A. Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on L-carnitine supplementation. Colon-Soto, M., Peredo, R. A., and Vila, L. M. Systemic lupus erythematosus after mesotherapy with acetyl-L-carnitine. Invest Clin 2007;48(2):243-248. Generic name: levocarnitine (oral) [LEE-voe-KAR-ni-teen] L-Carnitine is a naturally occurring substance that the body needs for energy. Siriraj Med.J. JPEN J Parenter.Enteral Nutr 1988;12(6):555-562. View abstract. View abstract. Cochrane.Database.Syst.Rev. Bonavita, E. Study of the efficacy and tolerability of L-acetylcarnitine therapy in the senile brain. Clinical and biochemical effects. Yokoi, K., Ito, T., Maeda, Y., Nakajima, Y., Ueta, A., Nomura, T., Koyama, N., Kato, I., Suzuki, S., Kurono, Y., Sugiyama, N., and Togari, H. Acylcarnitine profiles during carnitine loading and fasting tests in a Japanese patient with medium-chain acyl-CoA dehydrogenase deficiency. Current Therapeutic Research 1986;39(3):429-435. L-carnitine supplementation of a soybean-based formula in early infancy: plasma and urine levels of carnitine and acylcarnitines. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. View abstract. As a supplement, acetyl-L-carnitine is usually considered safe when taken as directed. View abstract. Fietta, P. and Manganelli, P. Carnitine: a therapeutic option for childhood psoriatic onycho-pachydermo-periostitis (POPP). View abstract. J Inherit.Metab Dis 2006;29(2-3):288-298. View abstract. You may report them to the FDA. Rodriguez DR, endible A, Gomez N, and et al. Touati, G., Valayannopoulos, V., Mention, K., de, Lonlay P., Jouvet, P., Depondt, E., Assoun, M., Souberbielle, J. C., Rabier, D., Ogier de, Baulny H., and Saudubray, J. M. Methylmalonic and propionic acidurias: management without or with a few supplements of specific amino acid mixture.
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