Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Do not mix iron sucrose with other medications or TPN solution. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Anemia; 2015: 763576. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Modify Therapy/Monitor Closely. Applies only to oral form of both agents. . The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Avoid or Use Alternate Drug. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. 1) Ganzoni AM. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. Included in the iron dextran package insert. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Avoid or Use Alternate Drug. I. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Applies only to oral form of both agents. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Administer Venofer early during the dialysis session (generally within the first hour). This drug is available at a higher level co-pay. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. informational and educational purposes only. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose, captopril. Applies only to oral form of both agents. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. This drug is available at the lowest co-pay. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Applies only to oral form of both agents. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Copyright(c) 2023 First Databank, Inc. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Injection site discoloration has been reported following extravasation. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. These can be input in g/dL, g/L or mmol/L. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Venofer is given as an infusion into a vein. Ferritin and transferrin are also recommended monitoring . Applies only to oral form of both agents. Applies only to oral form of both agents. Your doctor will do laboratory tests to monitor your response. Anemia caused by the depletion of iron is called iron deficiency anemia. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Use Caution/Monitor. Venofer has not been studied in patients younger than 2 years old. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. IDA diagnosis is based on full blood examination and on the serum ferritin level. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Minor/Significance Unknown. Applies only to oral form of both agents. Nutrition. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. 1 ,*. Copyright 1993-2021 Shirley, NY: American Regent, Inc.; 9/2020. Applies only to oral form of both agents. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Venofer treatment may be repeated if necessary. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Applies only to oral form of both agents. 1974 Jun;31(6):592-5. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. May increase risk of hypotension. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Use alternatives if available. . The iron formulation choice remains for the clinician to make. Applies only to oral form of both agents. Use Caution/Monitor. Pain, swelling, or redness at the injection site may occur. Consult your pharmacist or local waste disposal company. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. *Administer early during the dialysis session. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Use Caution/Monitor. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Can't find what you need? Minor/Significance Unknown. Avoid or Use Alternate Drug. Access your plan list on any device mobile or desktop. Interaction only with oral iron administration. Modify Therapy/Monitor Closely. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Avoid or Use Alternate Drug. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. There are physiological variation in iron reserves such as the decrease during menstruation period. Applies only to oral form of both agents. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Interaction only with oral iron administration. Last updated 28/06/2018 Enter values here and press 'Calculate'. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. Initial infusion rate. Minor (1)iron sucrose, benazepril. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Avoid or Use Alternate Drug. Deferoxamine chelates iron. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. If we don't have the calculator you need we'll try to make it for you and add it to the website. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Anemias. Am J HealthSyst Pharm 2006;63:731735. Minor/Significance Unknown. Use Caution/Monitor. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Minor/Significance Unknown. Avoid or Use Alternate Drug. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Use Caution/Monitor. Avoid or Use Alternate Drug. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Am J Hosp Pharm. Venofer must only be administered intravenously either by slow injection or by infusion. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Avoid or Use Alternate Drug. iron sucrose, benazepril. FERAHEME met the predefined criteria for non-inferiority to Venofer . If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Copyright 2021 GlobalRPH - Web Development by. Adding plans allows you to compare formulary status to other drugs in the same class. Accessed: 4/12/2011. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. David McAuley, Pharm.D. Reactions have occurred following the first dose or subsequent doses of Venofer. 5. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Modify Therapy/Monitor Closely. Although the original formula requires the weight in kilograms, values input in lbs are transformed. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. You may report side effects to Health Canada at 1-866-234-2345. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Intravenous iron-dextran: therapeutic and experimental possibilities. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. The dosage of Venofer is expressed in mg of elemental iron. This calculator will help pinpoint potential causes of anemia based on No additional iron to replenish stores. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] however iron sucrose requires multiple small intermittent doses over days to weeks. Use Caution/Monitor. Avoid or Use Alternate Drug. Hollands J, Foote E, Rodriguez A. Many patients with kidney disease cannot get enough iron from food and require injections. . In the text below the tool there is more information on how the iron deficit is calculated. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Administer on 5 different occasions over a 14 day period. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Use Caution/Monitor. Use Caution/Monitor. Dosing: (a) Divide calculated total cumulate dose . Drug class: Iron products. Modify Therapy/Monitor Closely. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer may reduce the absorption of concomitantly administered oral iron preparations. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to We'll do this entirely for free, as long as the calculator has applications for women's health. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Either decreases levels of the other by inhibition of GI absorption. If you log out, you will be required to enter your username and password the next time you visit. This website is intended for use by US healthcare professionals only. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. World J Gastroenterol; 16(22): 27202725. Minor/Significance Unknown. Canada residents can call a provincial poison control center. VenAccess is a trademark of Vifor (International) Inc. Switzerland. commonly, these are generic drugs. Applies only to oral form of both agents. iron sucrose decreases levels of minocycline by inhibition of GI absorption. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g.
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