Most people with factor V Leiden never develop abnormal clots. 3. 0000008077 00000 n
(accessed March 04, 2023). Venous thromboembolism. As they come, write them down. Or maybe youve had no issues, but your loved one needed treatment for DVT. A DVT may not cause any symptoms. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. How long will it take to get results back? 0
Hereditary thrombophilia. Avoidance of alcohol-containing beverages during long flights. 0000001362 00000 n
However, there are things that you can do to reduce your chances of developing a dangerous blood clot. The Top 5 Worst Foods for Your Heart, According to a Dietitian. Want to talk about Multiple Myeloma: Anyone else? In a healthy individual who is bleeding, platelets and clotting factors or specific proteins form a clot to stop the bleeding. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. However, interactions with food, drinks, herbs, and other medications may still occur. 0000237061 00000 n
Take frequent breaks during long car rides to get out and stretch your legs. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. If you notice any of these problems, call your doctor right away. If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Deep vein thrombosis and pulmonary embolism. It is generally advised that patients taking anticoagulants keep to a balanced and consistent diet balanced throughout their treatment course to avoid fluctuations in treatment efficacy. In rare cases, you may need a catheter procedure or surgery to remove the bulk of the clots. Cooking and shopping: Youll spend minimal time and effort on cooking if you stock your refrigerator and pantry with Pasternaks top picks for 5-Factor foods. The clot remains in place while other enzymes repair the damaged blood vessel. If you have the prothrombin gene mutation but never had a deep vein thrombosis or pulmonary embolism before, you will not need a blood thinner during or after pregnancy. A blood test (called a screening test) can show if you have Activated Protein C resistance. Accessed June 4, 2018. If you are already taking an anticoagulant, make sure you keep regular appointments with your provider. WebMD does not provide medical advice, diagnosis or treatment. Talk to your healthcare provider to receive advice tailored to your needs. Vitamin K is a necessary element in the blood clotting process. This caution also extends to drug-food interactions. A single copy of these materials may be reprinted for noncommercial personal use only. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. Does It Allow for Dietary Restrictions or Preferences? How frequently do I need to have checkups. We inherit one gene from our mother and one from our father. Factor V Leiden is the most common inherited condition causing increased blood clotting. Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome. 2. All rights reserved. 0000006483 00000 n
Low Vitamin K consumption if on Coumadin/Warfarin. Fiber (whole-grain cereal, beans, wild rice, flourless wheat bread. Calorie counting is not a feature of this diet plan. Factor V Leiden is a mutation of the genes that causes impairment to the normal process of blood clotting. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Accessed June 4, 2018. Get useful, helpful and relevant health + wellness information. She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. Both of those types of injectable blood thinners are safe for your baby. If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. This disorder may raise your risk of a miscarriage or other complications. People with factor V Leiden have a mutation in their coagulation factor V (F5) gene. <]>>
Accessed June 4, 2018. When taken with anticoagulants, binge-drinking alcohol can increase INR values. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? Can the results of the test affect my ability to obtain health insurance? A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. There is also a 50% chance that your child will inherit your normal Factor V gene. Gluten-free: The breads Pasternak allows are flour-free. Food choices are varied enough that you can have a balanced diet and not get bored of foods. Study shows COVID-19 rates were likely forty-times higher than CDC estimates during BA.4/BA.5 dominant period in the U.S. Popular artificial sweetener associated with elevated risk of heart attack and stroke, study shows, Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall, New method can potentially catch COVID-19 infections quickly with near-perfect accuracy, Evidence that cross-reactive immunity from common human coronaviruses can influence response to SARS-CoV-2, The Effect of Intermittent Fasting on the Gut Microbiome, The Impact of Cyberbullying on Mental Health, Association between cardiovascular disease and transportation noise revealed in new research, Novel predictors of severe respiratory syncytial virus infections among infants below the age of one, Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method, Innovative method to spot bacteria in blood, wastewater, and more, Associations between structural brain alterations and post-COVID fatigue. Though exercise is an important part of the 5-Factor Diet, the recommended amount falls a bit short of the 150 minutes a week of aerobic activity coupled with strength training that most experts recommend. However, your doctor might suggest that you take extra precautions to prevent blood clots if you have the factor V Leiden mutation and are going to have surgery. Symptoms may resolve within days or months, depending on the location and severity of your deep vein thrombosis or pulmonary embolism. 4. 0000002579 00000 n
There are many programs, websites and tools that can help you quit. Cranberry products are not significant unless taken in high amounts, as for urinary infections. 0000001440 00000 n
But its important that these individuals discuss with their doctors what they should be aware of and what they can do to minimize the risk of DVT or PE. 0000239923 00000 n
Talk with your health care provider about how to do this safely. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. This is why Factor V Leiden is sometimes called Activated Protein C Resistance and why people with this mutation clot more than those without it. Policy. But the plan would have to be modified to make it appropriate if you have these or other conditions. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. If you are homozygous, you will pass the mutation on to your children. . Recurrent fetal loss during the second or third trimester suggests an inherited thrombophilia or antiphospholipid antibody. 0000229756 00000 n
If I have children, do they need to be tested? A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. Most people with factor V Leiden never develop abnormal clots. Most people who inherit it never develop abnormal blood clots, and may never even know they have the disorder. This gene is responsible for aiding in normal blood clotting. Accessed June 4, 2018. Start With This 7-Day Meal Plan, 10 Effortless Ways to Finally Cut Down on Salt. About 1 of every 250 Black people in America has the prothrombin gene mutation. 8( x@YB.X0v@+::0Xv|@Q-s4>p03(/` `F0.oCD8}.n)2`b#jPv!A CPt k*6@)V+`b@@\crT0. Green tea in high amounts could reduce PT-INR values. Prevention and Treatment of Excessive Blood Clotting (Hypercoagulation). For children with one affected gene, the chance of getting a blood clot increases 10 times. Eat well. But not everyone with the prothrombin gene mutation and a history of deep vein thrombosis or pulmonary embolism needs blood thinners during pregnancy. National Library of Medicines list But if you do, prompt treatment can manage your condition. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: 1. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. Diets ideal for this include the Mediterranean diet and the DASH diet. Alcohol interacts with a large number of medications. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. In a worst-case scenario, it lands in your legs, leading to deep vein thrombosis, or your lungs, forming a pulmonary embolism. Results from the PT test are expressed as a ratio called the international normalized ratio (INR). One or both of the factor V genes can be mutated and cause the altered form of the factor V protein known as the Factor V Leiden protein to be made. Some people do not have the normal Factor V protein. Bauer KA. Do you recommend genetic testing for any of my family members? You won't go hungry on The 5-Factor Diet. Instead, they have an different form called Factor V Leiden. But if you do, prompt treatment can manage your condition. Tips on transitioning to a whole food fertility diet. The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. Advertising on our site helps support our mission. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. 0000000016 00000 n
In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, Thomas SH, eds. What can I do to help prevent blood clots from forming? https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Laboratory testing (blood tests) diagnose this disorder. Factor V Leiden is a blood clotting disorder. This will help to avoid miscarriage or pregnancy complications for the following reasons: . You may substitute gluten-free alternatives as long as they are low-sugar. Foods containing trans fat, including hydrogenated oils and highly processed shelf-stable food (think: packaged snacks and baked goods). They are used to treat conditions such as embolic ischemic stroke, deep vein thrombosis, and pulmonary embolism. You may be treated with blood thinners until the risk has passed. Some people do not have the normal Factor V protein. (https://pubmed.ncbi.nlm.nih.gov/34540419/), (https://www.genome.gov/Genetic-Disorders/Factor-V-Leiden-Thrombophilia), (https://medlineplus.gov/lab-tests/coagulation-factor-tests/), (https://medlineplus.gov/genetics/gene/f5/), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). Having Factor V Leiden does not appear to increase the chances of developing a heart attack or stroke. What will a positive or negative result tell me? Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. Often, those treatments will require hospitalization. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. Take your questions to your healthcare provider and get the answers you need. Fatty fish: Aim for two servings of fatty fish each week, such as salmon, tuna and sardines. Retrieved on March 04, 2023 from https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). But if you do develop clots, be assured there are treatments that can help. That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. Kaushansky K, et al., eds. Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). 2019. Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. Factor V Leiden follows an autosomal dominant inheritance pattern. But when a person is diagnosed with an acute deep vein thrombosis (DVT) or pulmonary embolism (PE), treatment with anticoagulants (blood thinners) will be necessary and should be started as soon as possible. "Anticoagulant Food-Drug Interactions". One of these factors is Factor V (FV) Leiden (rs6025), which is a missense variant caused by a single nucleotide polymorphism (SNP) in the F5 gene. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. However, the disorder raises your risk compared to people without the disorder. Swelling in your leg or arm, which may appear suddenly. You do need treatment with blood thinners if you have had a blood clot or develop one in the future. As a result, clotting goes on longer than usual. Kaushansky K, et al., eds. A prothrombin gene mutation can raise your risk of getting a pulmonary embolism or deep venous thrombosis. Why Am I Still Anemic After Taking Iron Supplements? This means that for children with factor V Leiden, one out of 5,000-10,000 will get a blood clot. Advertising revenue supports our not-for-profit mission. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. 9th ed. Factor V that becomes impaired can cause numerous issues with the health of the human blood. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). Build physical activity into your daily life. If you have symptoms of a pulmonary embolism, you should go to the closest emergency room. It has been suggested as a risk factor for RPL as it triggers thrombophilia and impairs the initial vascularization process at implantation [ 6 ]. National Heart, Lung, and Blood Institute. 5. Added sugars in excess of 24 grams per day for people assigned female at birth and 32 grams per day for people assigned male at birth, per the American Heart Association. 76 0 obj<>
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Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. Try to build up to 150 minutes of moderate-intensity. Factor V Leiden resists the effects of Activated Protein C, so it takes longer to turn off Factor V Leiden. But your provider can help you keep your blood from clotting too much. The questions may keep coming, and thats normal. There are many foods that can be beneficial to the health of patients with Factor V Leiden. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. What information will come out of the test? Where's the Health Benefit? Late in my pregnancy I started having horrible swelling in my legs. In: Williams Hematology. Inheriting two copies one from each parent significantly increases your risk of developing blood clots. Here are a few to help you start the conversation: Factor V is a coagulation factor, or protein, in your blood. People with this condition have a factor V Leiden mutation, meaning theres a change in their coagulation factor V (F5) gene. Factor V is a protein that is needed for blood to clot properly. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Interactions which affect the efficacy of VKAs may result in bleeding from over-anticoagulation, or thrombosis due to under-anticoagulation. THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. DVT or a PE during or shortly following pregnancy. Its the most common blood clotting disorder thats inherited, or passed down within biological families. The 5-Factor Diet is a bundled diet and exercise plan that may help you lose weight and become more active. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. 0000001564 00000 n
Signs and symptoms may include: Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism. When you are ready, talk with your health care provider for advice and help to lose weight. These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. Blood clots in less commonly affected veins, like those in your liver or brain. of signs you need emergency medical attention or call 911. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. If you have kidney disease, there may be too much protein in this diet for you. Chan School of Public Health. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. (2019, May 20). Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. Mayo Clinic, Rochester, Minn. June 17, 2018. (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). She graduated from the University of Sussex with a BA in Media Practice, having specialized in screenwriting. Youre might be wondering, Will this happen to me? Last reviewed by a Cleveland Clinic medical professional on 10/04/2022. %PDF-1.5
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The prothrombin gene mutation can make you more likely to get harmful blood clots, but you may never get one. You inherited one Factor V Leiden gene from your mother and one from your father. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Your doctor can tell you how much fluid is right for your age, health and activity level. A cough that produces bloody or blood-streaked sputum. .wpcdt-timer-24806 {background-color: #aaaaaa;}.wpcdt-timer-24806 .wpcdt-title, .wpcdt-timer-24806 .wpcdt-desc, .wpcdt-timer-24806 .wpcdt-desc p{color: #b81d32;}.wpcdt-timer-24806 .wpcdt-clock-circle h4, Some research shows that factor V Leiden impacts pregnancy. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. 2. PO Box 825687 Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. You might have heard that "you can't choose your family," and the same applies to the genes you inherit from them. Its important to go to all of your appointments and talk to your provider about any questions or concerns you have. Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. Foods to limit when you're following a heart-healthy diet include: 1. Study Results Demonstrate VTE Treatment Satisfaction Among Patients, Managing Anticoagulants Before, During, and After Medical Procedures, Helping Women Make Choices About Contraception Following DVT Blood Clots, Panel Discussion: Blood Clots & Womens Health, Frequently Asked Questions: COVID-19 and Blood Clotting, Stop the Clot, Spread the Word Hospitalization, Toolkit for Knee and Hip Replacement Patients, Health Disparities and the VTE Mississippi Initiative, Atrial Fibrillation (AFib) and Clot-Provoked Stroke, Questions to Ask Your Doctor After Having a Blood Clot, NBCA Atrial Fibrillation Awareness Survey, Impact of Blood Clots in the Black Community Research Opportunities, NBCA Sports & Wellness Institute: Team Stop the Clot, Council of Emerging Researchers in Thrombosis (CERT), Medical & Scientific Advisory Board (MASAB), not enough clotting power leads to bleeding problems, too much clotting power can lead to the formation of dangerous blood clots. This site complies with the HONcode standard for trustworthy health information: verify here. Otherwise, all your meals should be limited to dishes made with foods from the five must-have groups mentioned above. 0000003776 00000 n
If you are heterozygous, theres a 50% chance that your children will get the mutation. Inherited thrombophilias in pregnancy. You probably wont know you have prothrombin gene mutation unless you have a specific blood test if/after you develop a deep vein thrombosis or pulmonary embolism. This content does not have an English version. Up to 1 in 50 people who are Black, Hispanic or Native American. 3. Limitations: You can eat anything you want on your weekly cheat day."
Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: Advertisement 1. Posted May 16, 2017 by Rachael 1000 Good Foods If you have been diagnosed with Factor V Leiden, you should alter your diet to prevent excessive blood clotting. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. Even if you develop a blood clot, prompt treatment can prevent a fatal outcome. Yes, you may be able to donate blood if youre not taking a blood thinner. xb```eB cg`a!OF'96L``XkeWp)8MenQLe*.,j(bicIgBvMS &"T$T'da[[N(~vS$ECp^e ^Ve'/ In most people, a protein called activated protein C regulates the activity of . 0000001706 00000 n
Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. If you get the mutation from both of your parents, you are homozygous (you have two abnormal copies of the Factor II gene). Please note that medical information found
If you believe Although the prothrombin gene mutation is the second most common inherited predisposition to a deep vein thrombosis or pulmonary embolism, it is the weakest of all inherited clotting disorders in terms of risk of causing abnormal blood clots. Its also important to talk to your provider: Seek emergency medical care if you develop symptoms of deep vein thrombosis or a pulmonary embolism. Inheriting one copy slightly increases your risk of developing blood clots. This content does not have an Arabic version. Women have a greater chance of developing a blood clot during pregnancy. Most people with factor V Leiden never develop abnormal clots. Your child will have either the heterozygous or homozygous type, depending on whether the gene passed down from his or her other parent is normal (Factor V) or abnormal (Factor V Leiden). Is this an emergency? DVT or a PE soon after starting birth control pills or hormone therapy. Factor V Leiden is the most common inherited condition that causes an increase in blood clotting. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. Factor V is a protein that is needed for blood to clot properly. Harvard T.H. Medicines help treat and prevent blood clots in people who are high risk for them. This change causes it to resist other proteins that stop excessive clotting. In this article, News-Medical talks to Sartorius about biosensing and bioprocessing in gene therapy, ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). Avoid smoking, vaping and tobacco use. This is your bodys reaction to an injury that prevents you from bleeding too much. Most people have never heard of Factor V Leiden. The disorder is most common in people who are white and of European descent. Owned and operated by AZoNetwork, 2000-2023. US Pharm. Is an uncertain result possible, and what would that mean? 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). The different gene that makes the Factor V Leiden protein is inherited from one or both parents. Have had clots two or more different times in the past. Genetic and Rare Disease Information Center. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge. Where's the Beef? Factor V Leiden is the name of one such blood clotting disorder. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either Both men and women can have factor V Leiden. Cleveland Clinic is a non-profit academic medical center. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. In 2010 I was pregnant with my son. This makes blood clots more likely to form, a condition called thrombophilia. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. A. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies.